Engineering more resilient crops for a warming climate
AI Summary: Researchers at Michigan State University, led by Berkley Walker, utilized AlphaFold to predict the 3D structure of the glycerate kinase (GLYK) enzyme, crucial for photosynthesis, to enhance its heat tolerance. Their findings revealed that three flexible loops in the plant version of GLYK destabilized at elevated temperatures, compromising its function. By creating hybrid enzymes that incorporated more rigid loops from a heat-tolerant algal version of GLYK, the team developed a variant that maintained stability at temperatures up to 65 °C. This work aims to inform the development of crops better suited to withstand the challenges posed by global warming.